E-GEOD-47553 - Effect of progerin on p53-deficient vascular smooth muscle cells
Released on 22 September 2013, last updated on 3 June 2014
Analysis of p53-deficient (E6-expressing) human vascular smooth muscle cells (VSMCs) that express progerin, a mutated form of lamin A resposible for Hutchinson- Gilford progeria syndrome (HGPS). p53 pathway is associated with HGPS. Results provide insight into molecular mechanisms underlying vascular dysfunction of HGPS caused by other than p53 pathway. The gene expression of VSMCs induced to express E6 and either lamin A or progerin by retroviral vectors.
transcription profiling by array
Daisuke Kinoshita <firstname.lastname@example.org>, Kazuhiro Sato, Masakatsu Yamashita