E-GEOD-474 - Transcription profiling of human skeletal muscle from obese vs.normal individuals to identify the mRNA of proteins involved in fat oxidation that may be reduced in obese and morbidly obese individuals
Released on 28 September 2007, last updated on 30 April 2015
It has been found that fat oxidation is reduced in the skeletal muscle of obese humans. This study aims to identify the mRNA of proteins involved in fat oxidation that may be reduced in obese and morbidly obese individuals. Information gathered will help in understanding how obesity contributes to cardiovascular disease via insulin resistance. Samples were obtained from patients undergoing elective abdominal surgery.
transcription profiling by array, co-expression, disease state
GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle. Jung-Jun Park,Jason R Berggren,Matthew W Hulver,Joseph A Houmard,Eric P Hoffman.