E-GEOD-47216 - The Obesity-associated Fto gene regulates activity of the dopaminergic midbrain circuitry [FTO KO]

Released on 15 June 2013, last updated on 4 July 2013
Mus musculus
Samples (6)
Protocols (4)
Here we use MeRIP-Seq to analyze global adenosine methylation (m6A) in mRNAs in the midbrain and striatum of Fto-deficient mice. We find that Fto deficiency leads to increased methylation within a subset of mRNAs important for neuronal signaling, including many within the dopaminergic signaling pathway. Collectively, our results show that Fto regulates demethylation of specific mRNAs in vivo, and this activity relates to control of dopaminergic transmission. Profiling of m6A in midbrain and striatum from FTO knockout mice
Experiment types
other, methylation profiling by high throughput sequencing 
Christopher Mason <geo@ncbi.nlm.nih.gov>, Bengt F Belgardt, Hella S Brönneke, Jens C Brüning, Kate D Meyer, Linda A Verhagen, Linda Koch, Marcelo O Dietrich, Martin E Hess, Olivier Elemento, Peter Kloppenburg, Sabine D Jordan, Samie R Jaffrey, Simon Hess, Tamas L Horvath, Thomas Franz, Ulrich Rüther
Exp. designProtocolsVariablesProcessedSeq. reads
Investigation descriptionE-GEOD-47216.idf.txt
Sample and data relationshipE-GEOD-47216.sdrf.txt
Additional data (1)E-GEOD-47216.additional.1.zip