E-GEOD-47187 - Analysis of differentially expressed genes in placental tissues of Pre-eclampsia Using microarray combined with Connectivity Map database

Status
Released on 1 October 2013, last updated on 3 June 2014
Organism
Homo sapiens
Samples (10)
Array (1)
Protocols (7)
Description
Preeclampsia (PE), which affects 2-7% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. To better understand the pathophysiology of PE, gene expression profiling of placental tissue from 5 controls and 5 PEs were assessed using microarray. A total of 224 transcripts were identified as being significantly differentially expressed (fold change > 2 and q value < 0.05 in the SAM software), GO enrichment analysis indicated that genes involved hypoxia, oxidative and reductive processes were significantly changed. Ten differentially expressed genes (DEGs) involved in these biological process were further verified by quantitative real-time PCR. Finally, the potential therapeutic agents for PE were explored via Connectivity Map database . In conclusion, the data obtained in this study might provide clues to better understand the pathophysiology of PE and found potential therapeutic agents for PE patients. gene expression profiling of placental tissue from 5 controls and 5 PEs were assessed using microarray.
Experiment type
transcription profiling by array 
Contacts
wang liang <llwang@biochainbj.com>, Juntao Liu, Liang Zhang, Saiqiong Huang, Yingna Song
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-47187.idf.txt
Sample and data relationshipE-GEOD-47187.sdrf.txt
Raw data (1)E-GEOD-47187.raw.1.zip
Processed data (1)E-GEOD-47187.processed.1.zip
Array designA-GEOD-14550.adf.txt
Links