E-GEOD-46904 - Gene expression profiles of EZH2 knockdown

Status
Released on 28 October 2013, last updated on 4 November 2013
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (7)
Description
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in MPNST pathogenesis. Our findings enhance the knowledge of EZH2’s function and biology, and have the potential to provide a novel therapeutic approach for MPNST patients in the clinic. An EZH2 knockdown experiment was carried out in MPNST cells. There are one control and one siEZH2 samples for two cell lines (724 and 462) and two repeats for each cell line, so in total there are 8 samples. Two group comparison
Experiment type
transcription profiling by array 
Contacts
Chad Creighton, Dina Lev, Pingyu Zhang, Yiqun Zhang
Citation
EZH2/miR-30d/KPNB1 pathway regulates malignant peripheral nerve sheath tumor cell survival and tumorigenesis. Zhang P, Garnett J, Creighton CJ, Sannaa GA, Igram DR, Lazar A, Liu X, Liu C, Pollock RE. , Europe PMC 24132643
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-46904.idf.txt
Sample and data relationshipE-GEOD-46904.sdrf.txt
Raw data (1)E-GEOD-46904.raw.1.zip
Processed data (1)E-GEOD-46904.processed.1.zip
Array designA-GEOD-10904.adf.txt
Links