E-GEOD-46671 - A broad array of anticancer activities of the immunosuppressive drug mycophenolic acid (MPA) is suggested by pathway analyses of gene expression and validated by proteomic and functional assays

Status
Released on 28 October 2013, last updated on 3 June 2014
Organism
Homo sapiens
Samples (12)
Array (1)
Protocols (5)
Description
Gene expression microarray was performed to assess the global changes coupled to targeted validation of proteomic profiling to reveal the broad anticancer activities of the immunosuppressive drug Mycophenolic acid (MPA) and elucidate the molecular mechanisms underlying these activities. We conducted gene expression microarray experiments on AGS cancers cells treated with Mycophenolic acid (MPA). A concentration of 2ug/ml was selected to treat AGS cells and the treated cells were harvested at 0, 12, 24, 48 and 72 hours of culture with the drug. Gene expression analyses were carried out using Illumina Human 12 Beadchips.
Experiment type
transcription profiling by array 
Contacts
Jin-Xiong She <jshe@gru.edu>, Ashok Sharma, Boying Dun, Haitao Liu, Heng Xu, Jin X She, Lingwen Zeng, Sharad Purohit, Yong Teng
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-46671.idf.txt
Sample and data relationshipE-GEOD-46671.sdrf.txt
Processed data (1)E-GEOD-46671.processed.1.zip
Array designA-MEXP-1171.adf.txt
Links