E-GEOD-46496 - Atrial Identity Is Determined by A COUP-TFII Regulatory Network (RNA)

Status
Released on 7 June 2013, last updated on 3 June 2014
Organism
Mus musculus
Samples (9)
Array (1)
Protocols (5)
Description
Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP- TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T-tubules. We used microarrays to examine the molecular profile of cardiomyocyte-specific COUP-TFII knockout adult atria in comparison with that of normal atria. We extracted RNA from mutant right atria, control right atria and control ventricles from 2 months old adult mice, followed by gene expression profiling using Affymetrix microarrays.
Experiment type
transcription profiling by array 
Contacts
San-pin Wu <geo@ncbi.nlm.nih.gov>, Ming-Jer Tsai, Sophia Y Tsai
Citation
Atrial Identity Is Determined by a COUP-TFII Regulatory Network. Wu SP, Cheng CM, Lanz RB, Wang T, Respress JL, Ather S, Chen W, Tsai SJ, Wehrens XH, Tsai MJ, Tsai SY. , Europe PMC 23725765
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-46496.idf.txt
Sample and data relationshipE-GEOD-46496.sdrf.txt
Raw data (1)E-GEOD-46496.raw.1.zip
Processed data (1)E-GEOD-46496.processed.1.zip
Array designA-AFFY-45.adf.txt
Links