E-GEOD-46287 - A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice

Status
Released on 9 October 2013, last updated on 3 June 2014
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (7)
Description
Tmprss6 is the master inhibitor of hepcidin and its inactivation causes iron refractory iron deficiency anemia both in human and in mice. Mice with iron deficiency anemia (IDA)-low hepcidin show a pro-inflammatory response that is blunted in iron deficienct-high hepcidin Tmprss6 null mice. We investigated the transcriptional response associated with chronic hepcidin overexpression by comparing whole genome transcription profiling of the liver of Tmprss6 KO mice and IDA animals, irrespective of iron deficiency. Total liver RNA obtained from Tmprss6 KO mice were compared to wild type (iron deficient) animals, under basal conditions and after LPS challenge
Experiment type
transcription profiling by array 
Contacts
Alessia Pagani, Antonella Nai, Clara Camaschella, Davide Cittaro, Elia Stupka, Filippo Martinelli Boneschi, Jose M Garcia Manteiga, Laura Silvestri, Marco Rausa, Melissa Sorosina, Michela Riba
Citation
A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice. Riba M, Rausa M, Sorosina M, Cittaro D, Garcia Manteiga JM, Nai A, Pagani A, Martinelli-Boneschi F, Stupka E, Camaschella C, Silvestri L. , Europe PMC 23922777
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-46287.idf.txt
Sample and data relationshipE-GEOD-46287.sdrf.txt
Processed data (1)E-GEOD-46287.processed.1.zip
Array designA-MEXP-1175.adf.txt
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