E-GEOD-46057 - Investigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of SH-42 and SH-80

Status
Released on 16 April 2013, last updated on 3 June 2014
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (7)
Description
In this study, we demonstrate that SH-42 and SH-80, novel heat shock protein 90 inhibitors, suppress retinal neovascularization via inhibition of hypoxia-mediated angiogenesis. To figure out any genotoxic effect of these compounds related with heat shock protein 90 inhibition, we performed microarray analyses with retinal tissues treated with SH-42 and SH-80 for 7 days. We intravitreally injected PBS, SH42, or SH80 into the right eyes of C57BL/6 male mice (n = 12 per group). PBS-treated mice were regarded as negative control. Four retinal tissues were pooled into 1 test tube and prepared for further analyses.
Experiment type
transcription profiling by array 
Contacts
Dong Hyun Jo <geo@ncbi.nlm.nih.gov>, Chang S Cho, Dong H Jo, Hongchan An, Hyoung-Oh Jun, Jeong-Hun Kim, Jin-Hyoung Kim, Young-Ger Suh
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-46057.idf.txt
Sample and data relationshipE-GEOD-46057.sdrf.txt
Raw data (1)E-GEOD-46057.raw.1.zip
Processed data (1)E-GEOD-46057.processed.1.zip
Array designA-GEOD-11202.adf.txt
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