E-GEOD-46057 - Investigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of SH-42 and SH-80
Released on 16 April 2013, last updated on 3 June 2014
In this study, we demonstrate that SH-42 and SH-80, novel heat shock protein 90 inhibitors, suppress retinal neovascularization via inhibition of hypoxia-mediated angiogenesis. To figure out any genotoxic effect of these compounds related with heat shock protein 90 inhibition, we performed microarray analyses with retinal tissues treated with SH-42 and SH-80 for 7 days. We intravitreally injected PBS, SH42, or SH80 into the right eyes of C57BL/6 male mice (n = 12 per group). PBS-treated mice were regarded as negative control. Four retinal tissues were pooled into 1 test tube and prepared for further analyses.
transcription profiling by array
Dong Hyun Jo <email@example.com>, Chang S Cho, Dong H Jo, Hongchan An, Hyoung-Oh Jun, Jeong-Hun Kim, Jin-Hyoung Kim, Young-Ger Suh