E-GEOD-4587 - Transcription profiling of human normal skin, benign and atypical nevi, and early and advanced-stage melanomas to gain insights into the genetic profile of every stage of the melanoma progression pathway
Submitted on 31 March 2006, released on 14 December 2007, last updated on 27 March 2012
To gain insights into the genetic profile of every stage of the melanoma progression pathway, and to determine to what extent these profiles are similar or distinct, we performed whole-genome expression profiling of tissue specimens representing normal skin, benign and atypical nevi, and early and advanced-stage melanomas. The results of this study provide first-time evidence that significant molecular changes occur distinctly at the border of/transition from melanoma in situ to primary melanoma, and that genes involved in mitotic cell cycle regulation and cell proliferation constitute the two leading categories of genes associated with these changes.
transcription profiling by array, cell type comparison, co-expression, disease state, individual comparison
Whole-genome expression profiling of the melanoma progression pathway reveals marked molecular differences between nevi/melanoma in situ and advanced-stage melanomas. Amanda Pfaff Smith,Keith Hoek,Dorothea Becker. Cancer biology & therapy :1018-29 (2005)