E-GEOD-4570 - Transcription profiling of normal human melanocytes and melanoma cell lines from advanced lesions
Submitted on 29 March 2006, released on 22 June 2007, last updated on 27 March 2012
Affymetrix oligonucleotide microarrays were used to assess global differential gene expression comparing normal human melanocytes with six independent melanoma cell strains from advanced lesions. The data, validated at the protein level for selected genes, confirmed the overexpression in melanoma cells relative to normal melanocytes of several genes in the growth factor/receptor family that confer growth advantage and metastasis. In addition, novel pathways and patterns of associated expression in melanoma cells not reported before emerged.
transcription profiling by array, co-expression, disease state
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Hoek K, Rimm DL, Williams KR, Zhao H, Ariyan S, Lin A, Kluger HM, Berger AJ, Cheng E, Trombetta ES, Wu T, Niinobe M, Yoshikawa K, Hannigan GE, Halaban R.