E-GEOD-4390 - Transcription profiling of mouse model of amyotrophic lateral sclerosis (ALS) vs. wild type

Status
Submitted on 7 March 2006, released on 14 December 2007, last updated on 27 March 2012
Organism
Mus musculus
Samples (6)
Array (1)
Protocols (6)
Description
mRNA expression in the spinal cords of the G93A-SOD1 familial ALS transgenic mouse model was compared to that in nontransgenic (Normal mouse) and transgenic mice expressing wild-type (WT)SOD1. Gene Ontology (GO)analysis was used to characterize differences in expression between G93A-SOD1 mouse and nontransgenic mouse spinal cord. Changes in multiple GO categories were found. Many of these were associated with subsystems involving cell-cell communication and intracellular signal transduction. Expression profiles of mice expressing WT-SOD1 did not differ from nontransgenic mice. In contrast, protein profiling using proteomics technology indicated changes in mitochondrial protein expression in the G93A-SOD1 mouse spinal cord that were not found in the mRNA expression analysis.
Experiment types
transcription profiling by array, individual genetic characteristics
Contact
Citation
Informatics-assisted protein profiling in a transgenic mouse model of amyotrophic lateral sclerosis. Thomas J Lukas,Wei Wei Luo,Haihong Mao,Natalie Cole,Teepu Siddique. Molecular & cellular proteomics : MCP :1233-44 (2006)
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-4390.idf.txt
Sample and data relationshipE-GEOD-4390.sdrf.txt
Processed data (1)E-GEOD-4390.processed.1.zip
Array designA-AFFY-6.adf.txt
Links