E-GEOD-4390 - Transcription profiling of mouse model of amyotrophic lateral sclerosis (ALS) vs. wild type
Submitted on 7 March 2006, released on 14 December 2007, last updated on 27 March 2012
mRNA expression in the spinal cords of the G93A-SOD1 familial ALS transgenic mouse model was compared to that in nontransgenic (Normal mouse) and transgenic mice expressing wild-type (WT)SOD1. Gene Ontology (GO)analysis was used to characterize differences in expression between G93A-SOD1 mouse and nontransgenic mouse spinal cord. Changes in multiple GO categories were found. Many of these were associated with subsystems involving cell-cell communication and intracellular signal transduction. Expression profiles of mice expressing WT-SOD1 did not differ from nontransgenic mice. In contrast, protein profiling using proteomics technology indicated changes in mitochondrial protein expression in the G93A-SOD1 mouse spinal cord that were not found in the mRNA expression analysis.
transcription profiling by array, individual genetic characteristics
Informatics-assisted protein profiling in a transgenic mouse model of amyotrophic lateral sclerosis. Thomas J Lukas,Wei Wei Luo,Haihong Mao,Natalie Cole,Teepu Siddique. Molecular & cellular proteomics : MCP :1233-44 (2006)