E-GEOD-43743 - ChIP-Seq of transcriptional regulators in MM1S cells upon small molecule treatment

Status
Released on 23 April 2013, last updated on 4 May 2014
Organism
Homo sapiens
Samples (7)
Protocols (8)
Description
Discovery of the genome-wide location of proteins using ChIP-Seq has allowed global mapping of the key transcription factors and chromatin regulators that control gene expression programs in various cells. Many DNA-associated processes are targeted for disease therapy. This study investigates the functions of small molecule therapeutics that target DNA-associated processes involved of CDK9 and BRD4. Genomic DNA was enriched by chromatin immunoprecipitation (ChIP) and analyzed by Solexa sequencing. ChIP was performed using an antibody against RNAP2, BRD4, CDK9, and CTCF using whole cell extract (WCE) as a background control.
Experiment type
ChIP-seq 
Contacts
Anders Lars, Heather Hoke, Rahl Peter, Richard A Young
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-GEOD-43743.idf.txt
Sample and data relationshipE-GEOD-43743.sdrf.txt
Processed data (1)E-GEOD-43743.processed.1.zip
Links