E-GEOD-43522 - Chromothripsis in AML

Status
Released on 4 August 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (2)
Array (1)
Protocols (7)
Description
This dataset contains data from two acute myeloid leukaemia (AML) specimens processed with the Illumina CytoSNP-12 SNP array platform. SNP array data showed evidence of chromothripsis in these two specimens. Each deletion in the mosaic specimen was present in the same proportion of cells, which supports the view that the many breaks occur as a single event. Complementary FISH studies highlighted the inclusion of centromeres from different chromosomes during the formation of the new chromosomes. Residual bone marrow specimens were chosen from patients who were determined to have a complex karyotype which included abnormalities of chromosomes 5 and 17, by routine cytogenetic examination.
Experiment types
genotyping by array, comparative genomic hybridization by array 
Contacts
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-43522.idf.txt
Sample and data relationshipE-GEOD-43522.sdrf.txt
Processed data (1)E-GEOD-43522.processed.1.zip
Array designA-GEOD-13829.adf.txt
Links