E-GEOD-42977 - Sequential Binary Gene-Ratio Tests Define a Novel Molecular Diagnostic Strategy for Malignant Pleural Mesothelioma

Status
Released on 1 May 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (117)
Array (1)
Protocols (5)
Description
The gene-expression ratio technique was used to design a molecular signature to diagnose MPM from among other potentially confounding diagnoses and differentiate the epithelioid from the sarcomatoid histological subtype of MPM. Microarray analysis was performed on 113 specimens including MPMs and a spectrum of tumors and benign tissues comprising the differential diagnosis of MPM. A sequential combination of binary gene-expression ratio tests was developed to discriminate MPM from other thoracic malignancies . This method was compared to other bioinformatic tools and this signature was validated in an independent set of 170 samples. Functional enrichment analysis was performed to identify differentially expressed probes.
Experiment type
transcription profiling by array 
Contacts
Assunta De Rienzo, Beow Y Yeap, John Quackenbush, Lucian R Chirieac, Melissa H Coleman, Peter E Sugarbake, Raphael Bueno, Roderick V Jensen, William G Richards, Yaoyu E Wang
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-42977.idf.txt
Sample and data relationshipE-GEOD-42977.sdrf.txt
Processed data (1)E-GEOD-42977.processed.1.zip
Array designA-GEOD-6790.adf.txt
Links