E-GEOD-42284 - Full genome expression profiling of primary colorectal cancer (CRC)
Released on 23 July 2013, last updated on 2 June 2014
Fresh-frozen primary tumor samples from CRC patients were analyzed from their gene expression. Full genome unsupervised clustering identified three intrinsic subtypes that are associated with tumor and clinical characteristics. Primary CRC samples (188) were hybridzed against a common colon cancer reference pool (CRP).
transcription profiling by array
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. Roepman P, Schlicker A, Tabernero J, Majewski I, Tian S, Moreno V, Snel MH, Chresta CM, Rosenberg R, Nitsche U, Macarulla T, Capella G, Salazar R, Orphanides G, Wessels LF, Bernards R, Simon I. , Europe PMC 23852808