E-GEOD-41831 - Remission in Juvenile Idiopathic Arthritis Achieved on Different Drug Regimens

Status
Released on 24 October 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (78)
Array (1)
Protocols (6)
Description
Remission has become both the gold standard for clinical care and the end point for clinical trials for children with juvenile idiopathic arthritis (JIA). Using gene expression microarrays, we found that when remission induced by methotrexate (MTX) or MTX plus a TNF inhibitor (etanercept, Et) (MTX+Et) was compared with healthy controls, there were notable differences in gene expression patterns, demonstrating that remission is not a restoration of immunologic normalcy. Differences were detected in PBMC as well as in granulocytes. Total RNA was extracted from isolated PBMC and granulocytes from patients with polyarticular JIA and from healthy controls. Patients had achieved remission (clinical remission on medicine as defined by Wallace et al, Arthritis Rheum. 2005;52(11):3354-3562) using either MTX or MTX+Et.
Experiment type
transcription profiling by array 
Contacts
Bart Frank
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-41831.idf.txt
Sample and data relationshipE-GEOD-41831.sdrf.txt
Raw data (2)E-GEOD-41831.raw.1.zip, E-GEOD-41831.raw.2.zip
Processed data (1)E-GEOD-41831.processed.1.zip
Array designA-AFFY-44.adf.txt
Links