E-GEOD-41497 - Development of Helicobacter pylori microarrays to test pathogenicity of clinical isolates

Status
Released on 5 August 2013, last updated on 12 August 2013
Organism
Homo sapiens
Samples (18)
Array (1)
Protocols (7)
Description
To distinguish between Helicobacter pylori isolates that may cause greater disease in patients, we used whole genome expression profiling as a platform to study host-pathogen interactions and identify gene signatures associated with isolates from patients with higher cancer risk. Expression profiles were studied for 3 clinical isolates from a region of high gastric cancer incidence (PZ5056, PZ5080, PZ5086) in Colombia and 3 isolates from a region with low gastric cancer incidence in Colombia (PZ5004, PZ5024, PZ5026). Each experiment was done in triplicate by infecting monolayers of gastric epithelial cells for 1 hour with the isolates.
Experiment type
transcription profiling by array 
Contacts
Alexander Sheh, D S Merrell, James G Fox, Keith T Wilson, Pelayo Correa, Rupesh Chaturvedi
Citation
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-41497.idf.txt
Sample and data relationshipE-GEOD-41497.sdrf.txt
Raw data (1)E-GEOD-41497.raw.1.zip
Processed data (1)E-GEOD-41497.processed.1.zip
Array designA-GEOD-16166.adf.txt
Links