E-GEOD-41446 - Early molecular assessment of osseointegration in humans
Released on 17 September 2013, last updated on 26 September 2013
To determine the early temporal wide genome transcription regulation by the surface topography at the bone-implant interface of implants bearing micro-roughened or superimposed nanosurface topology. Fourty four cp titanium implants with surface topographies exhibiting nanoscale features (Osseospeed-OS) and microrough surface without nanoscale features (TiOblast-TiO) were placed in the alveolar bone of 11 systemically healthy subjects and subsequently harvested at 3 and 7 days after placement. Total RNA was isolated from cells adherent to retrieved implants. A whole genome microarray using the Affymetrix Human gene 1.1 ST Array was used to describe the gene expression profiles that were differentially regulated by the implant surfaces.
transcription profiling by array
Lyndon Cooper <email@example.com>, Ghadeer N Thalji, Lyndon F Cooper, Salvador Nares