E-GEOD-4142 - Transcription profiling of mouse naive B cells vs. antigen-specific plasma, germinal center, and memory B cells after immunization with the T-dependent antigen, NP-CGG, in order to generate a transcriptional profile of self-renewal within the hematopoietic system

Status
Submitted on 31 January 2006, released on 15 December 2007, last updated on 3 May 2014
Organism
Mus musculus
Samples (14)
Array (1)
Protocols (5)
Description
In order to better understand the factors that regulate B cell differentiation upon exposure to antigen, we compares global gene expression profiles from naive B cells with antigen-specific plasma, germinal center, and memory B cells after immunization with the T-dependent antigen, NP-CGG. The memory B cell-enriched transcripts were then compared with memory T cell-enriched and hematopoietic stem cell-enriched transcripts in order to generate a transcriptional profile of self-renewal within the hematopoietic system.
Experiment types
transcription profiling by array, co-expression, compound treatment
Contact
Citation
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Chance John Luckey,Deepta Bhattacharya,Ananda W Goldrath,Irving L Weissman,Christophe Benoist,Diane Mathis. Proceedings of the National Academy of Sciences of the United States of America :3304-9 (2006)
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-4142.idf.txt
Sample and data relationshipE-GEOD-4142.sdrf.txt
Raw data (1)E-GEOD-4142.raw.1.zip
Processed data (1)E-GEOD-4142.processed.1.zip
Array designA-AFFY-45.adf.txt
R ExpressionSetE-GEOD-4142.eSet.r
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