E-GEOD-41290 - Gene expression analysis of SCG sympathetic neurons with loss of Egr3

Status
Released on 22 March 2013, last updated on 2 June 2014
Organism
Mus musculus
Samples (6)
Array (1)
Protocols (6)
Description
The transcription factor Egr3 has been shown to have a cell autonomous role in sympathetic nervous system (SNS) development. We utilized microarray analysis to identify potential downstream target genes deregulated with loss of Egr3. Both conditions were in the null Bax background to prevent apoptosis and therefore mitigate identification of apoptosis related genes. Our analysis identified genes involved in biological processes that were expected such as SNS development and axonogenesis as well as those that were unexpected such as dendritogenesis and axon guidance. This led us to investigate whether Egr3 is important in these unexpected biological processes within sympathetic neurons. Total RNA was obtained from superior cervical ganglion (SCG) dissected from P0 mice with the genotype of Egr3+/+; Bax-/- or Egr3-/-; Bax-/-. Each genotype had 3 samples each.
Experiment type
transcription profiling by array 
Contacts
David Quach, Warren Tourtellotte
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-41290.idf.txt
Sample and data relationshipE-GEOD-41290.sdrf.txt
Processed data (1)E-GEOD-41290.processed.1.zip
Array designA-MEXP-933.adf.txt
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