E-GEOD-40999 - Th2 cytokine IL-4 is critical in initiating pulmonary vascular inflammation under hypoxic conditions and induces pulmonary vascular endothelial cell activation

Status
Released on 19 September 2013, last updated on 2 June 2014
Organism
Mus musculus
Samples (18)
Array (1)
Protocols (7)
Description
IL-4-mediated pro-inflammatory vascular responses have been implicated in the pathogenesis of chronic cardiopulmonary diseases. Our results show that hypoxia-induced collagen synthesis and early recruitment of inflammatory cells are significantly less in the lungs of IL-4 knockout (KO) mice than in those of wild-type mice. In addition, we found that IL-4 significantly increased pro-inflammatory genes in primary pulmonary microvascular endothelial cells. This study was designed to identify the gene expression profile of IL-4-dependent pulmonary vascular inflammation induced by hypoxia.
Experiment type
transcription profiling by array 
Contacts
chris cheadle <ccheadl1@jhmi.edu>, Chris Cheadle, Kazuyo Kegan
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-40999.idf.txt
Sample and data relationshipE-GEOD-40999.sdrf.txt
Processed data (1)E-GEOD-40999.processed.1.zip
Array designA-MEXP-1174.adf.txt
Links