E-GEOD-39786 - Expression data for knockdown of H2ac in E2-treated MCF-7 cell lines

Status
Released on 24 July 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (4)
Array (1)
Protocols (7)
Description
Estrogens(E2) are important steroid hormones that regulate differentiation, proliferation, and apoptosis in hormone-dependent breast cancer.In order to detect the E2-dependent transcription program associated with the observed cell cycle response, we analyzed the effect of H2ac knockdown on MCF-7 gene expression using microarray. Interestingly, we noticed that 51% of the E2-upregulated genes are down-regulated by depletion of H2ac. The data also show that H2ac regulated E2-dependent genes through E2-induction signaling pathway. MCF-7 cell line was transfected with scrambled or H2ac siRNA in the absence or persence of E2.
Experiment type
transcription profiling by array 
Contacts
CH Su <bluebroken0914@gmail.com>, Chia-Hsin Su, Ching Cheng, Ming-Ta Hsu
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-39786.idf.txt
Sample and data relationshipE-GEOD-39786.sdrf.txt
Raw data (1)E-GEOD-39786.raw.1.zip
Processed data (1)E-GEOD-39786.processed.1.zip
Array designA-AFFY-44.adf.txt
Links