E-GEOD-39591 - Tumoral transcriptome profiling of tPTEN-/- mice.
Released on 3 February 2014, last updated on 18 February 2014
tPTEN-/- mice display a deletion of the PTEN tumor suppressor gene specifically in T cells (cross PTEN flox/flox x lck-Cre). They develop T cell lymphoma with a primary thymic tumor and invasion of most organ at late stage of the disease. Gene profiling was performed on whole tumors (ST3 stage 3 invasive lymphoma) and normal thymocytes (wt) using Affymetrix-MoGene-1_0-st-v1 chips.
transcription profiling by array
Kevin Lebrigand <firstname.lastname@example.org>, B Mari, C Moreilhon, J F Peyron, K Lebrigand, P Barbry, V Imbert-rezzonico
Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas. Lounnas N, Rosilio C, Nebout M, Mary D, Griessinger E, Neffati Z, Chiche J, Spits H, Hagenbeek TJ, Asnafi V, Poulsen SA, Supuran CT, Peyron JF, Imbert V. , Europe PMC 23348702