E-GEOD-38690 - The ERRalpha metabolic nuclear receptor controls growth of colon cancer cells

Status
Released on 6 June 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (6)
Array (1)
Protocols (7)
Description
Estrogen-Related Receptor alpha (ERRα) is a nuclear receptor that acts principally as a regulator of metabolism processes particularly in tissues subjected to high-energy demand. Besides its implication in energy metabolism and mitochondrial biogenesis, ERRα was recently associated with tumorigenesis. Notably, increased expression of ERRα was noted in different cancerous tissues as breast, ovary and colon. However, supplemental studies are required to better understand the role of ERRα in colon carcinoma. We used microarrays to detail gene expression during ERRalpha knockdown in HCT116 cells and identified distinct classes of up and down-regulated genes. Triplicate of HCT116 cell line was infected witn shscrambled(shCTL) and shERRalpha lentivirus and used for RNA extraction and hybridization on Affymetrix microarrays.
Experiment type
transcription profiling by array 
Contacts
Julie Carrier <julie.carrier2@usherbrooke.ca>, André Carpentier, Gérald Bernatchez, Julie C Carrier, Nathalie Rivard, Thomas Lassalle, Véronique Giroux
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-38690.idf.txt
Sample and data relationshipE-GEOD-38690.sdrf.txt
Raw data (1)E-GEOD-38690.raw.1.zip
Processed data (1)E-GEOD-38690.processed.1.zip
Array designA-GEOD-10739.adf.txt
Links