E-GEOD-38075 - Profiling whole lung from lung-specific IL-1b-Tg mice

Status
Released on 22 March 2013, last updated on 2 June 2014
Organism
Mus musculus
Samples (8)
Array (1)
Protocols (7)
Description
This program aims at identifying the lung gene signature associated with inflammation and emphysema in IL-1b-Tg mouse COPD model to facilitate understanding of the disease mechanism and therapeutic compound testing The lung profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the lungs of IL-1b-Tg mice treated with doxycycline (to induce IL-1b transgene) compared to the corresponding water-treated controls.
Experiment type
transcription profiling by array 
Contacts
Citation
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers. Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C. , Europe PMC 22806142
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-38075.idf.txt
Sample and data relationshipE-GEOD-38075.sdrf.txt
Raw data (1)E-GEOD-38075.raw.1.zip
Processed data (1)E-GEOD-38075.processed.1.zip
Array designA-GEOD-6794.adf.txt
Links