E-GEOD-37874 - Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity

Status
Released on 8 June 2013, last updated on 2 June 2014
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (7)
Description
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were treated with either saline (PBS) or 100mg/kg APAP. Liver RNA was harvested eight hours after challenge and processed for microarray analysis. Comparison of 2 treatment conditions in 2 genotypes, biological replicates in triplicate.
Experiment type
transcription profiling by array 
Contacts
Ed Schmidt <eschmidt@montana.edu>, E E Schmidt, S V Iverson
Citation
A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification. Iverson SV, Eriksson S, Xu J, Prigge JR, Talago EA, Meade TA, Meade ES, Capecchi MR, Arn�r ES, Schmidt EE. , Europe PMC 23743293
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-37874.idf.txt
Sample and data relationshipE-GEOD-37874.sdrf.txt
Raw data (1)E-GEOD-37874.raw.1.zip
Processed data (1)E-GEOD-37874.processed.1.zip
Array designA-AFFY-36.adf.txt
Links