E-GEOD-37831 - In utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.

Status
Released on 4 June 2013, last updated on 17 June 2013
Organism
Mus musculus
Samples (34)
Array (1)
Protocols (7)
Description
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspring at 2 weeks of age. Pregnant Mice (BALB/c, C57BL/6, C3H/HeARC) mice were exposed to arsenic (or control) via drinking water from day 8 of gestation until the birth of their offspring. After giving birth, mothers were given control drinking water. At 2 weeks post-natal age, total RNA was extracted from peripheral lung tissue of the offspring and analysed on Affymetrix microarrays.
Experiment type
transcription profiling by array 
Contacts
Alexander N Larcombe, Anthony Bosco, Graeme R Zosky, Katherine L McKenna, Kathryn A Ramsey, Kim W Carter, Peter D Sly
Citation
In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice. Ramsey KA, Bosco A, McKenna KL, Carter KW, Elliot JG, Berry LJ, Sly PD, Larcombe AN, Zosky GR. , Europe PMC 23221970
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-37831.idf.txt
Sample and data relationshipE-GEOD-37831.sdrf.txt
Raw data (1)E-GEOD-37831.raw.1.zip
Processed data (1)E-GEOD-37831.processed.1.zip
Array designA-AFFY-130.adf.txt
Links