E-GEOD-37831 - In utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
Released on 4 June 2013, last updated on 17 June 2013
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspring at 2 weeks of age. Pregnant Mice (BALB/c, C57BL/6, C3H/HeARC) mice were exposed to arsenic (or control) via drinking water from day 8 of gestation until the birth of their offspring. After giving birth, mothers were given control drinking water. At 2 weeks post-natal age, total RNA was extracted from peripheral lung tissue of the offspring and analysed on Affymetrix microarrays.
transcription profiling by array
Alexander N Larcombe, Anthony Bosco, Graeme R Zosky, Katherine L McKenna, Kathryn A Ramsey, Kim W Carter, Peter D Sly
In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice. Ramsey KA, Bosco A, McKenna KL, Carter KW, Elliot JG, Berry LJ, Sly PD, Larcombe AN, Zosky GR. , Europe PMC 23221970