E-GEOD-37363 - TET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma (mRNA)

Status
Released on 10 October 2013, last updated on 22 October 2013
Organism
Homo sapiens
Samples (9)
Array (1)
Protocols (6)
Description
Global gene expression in TET2 mutant and Wild type patients. We performed an integrated analysis of global DNA methylation and gene expression data to investigate the effects of DNA hypermethylation on gene expression. Total RNA was isolated from 4 TET2mut and 5 TET2wt were isolated using standard RNAeasy kit protocol (Qiagen). Their gene expression profiles were obtained using the[HuGene-1_0-st] Affymetrix.
Experiment type
transcription profiling by array 
Contacts
Vasu Punj <vasu.punj@med.usc.edu>, Anders B Nielsen, Anja Pedersen, Christoffer Hother, Elisabeth Ralfkiaer, Fazila Asmar, Jesper Christensen, Kirsten Gronbaek, Kristian Helin, Marianne T Pedersen, Peter D Brown, Ulrik Ralfkiaer
Citation
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Asmar F, Punj V, Christensen J, Pedersen MT, Pedersen A, Nielsen AB, Hother C, Ralfkiaer U, Brown P, Ralfkiaer E, Helin K, Gr�nb�k K. , Europe PMC 23831920
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-37363.idf.txt
Sample and data relationshipE-GEOD-37363.sdrf.txt
Raw data (1)E-GEOD-37363.raw.1.zip
Processed data (1)E-GEOD-37363.processed.1.zip
Array designA-AFFY-141.adf.txt
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