E-GEOD-37362 - TET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma (DNA methylation)

Status
Released on 10 October 2013, last updated on 1 May 2015
Organism
Homo sapiens
Samples (31)
Array (1)
Protocols (6)
Description
Genome wide DNA methylation profiling of patient samples with TET2 mutations and Wild type TET2 status . The Illumina Infinium HumanMethylation 450_15017482_v.1.1 was used to obtain DNA methylation profiles across approximately 482,421 CpGs in fresh frozen lymphoma samples. Samples include 19 TET2 wild type and 12 TET2 mutant samples. Bisulphite converted DNA from the 31 samples were hybridised to the Illumina Infinium HM450K Human Methylation Beadchip v1.2
Experiment type
methylation profiling by array 
Contacts
Vasu Punj <vasu.punj@med.usc.edu>, Anders B Nielsen, Anja Pedersen, Christoffer Hother, Elisabeth Ralfkiaer, Fazila Asmar, Jesper Christensen, Kirsten Gronbaek, Kristian Helin, Marianne T Pedersen, Peter D Brown, Ulrik Ralfkiaer
Citation
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Asmar F, Punj V, Christensen J, Pedersen MT, Pedersen A, Nielsen AB, Hother C, Ralfkiaer U, Brown P, Ralfkiaer E, Helin K, Gr�nb�k K. , Europe PMC 23831920
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-37362.idf.txt
Sample and data relationshipE-GEOD-37362.sdrf.txt
Processed data (1)E-GEOD-37362.processed.1.zip
Additional data (1)E-GEOD-37362.additional.1.zip
Array designA-GEOD-13534.adf.txt
Links