E-GEOD-3681 - PHA-4 organogenesis

Status
Submitted on 25 November 2005, released on 25 November 2005, last updated on 27 March 2012
Organism
Caenorhabditis elegans
Samples (6)
Arrays (2)
Protocols (2)
Description
The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R = A/G, K = T/G, Y = T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes. A genotyping experiment design type classifies an individual or group of individuals on the basis of alleles, haplotypes, SNP's. Computed
Experiment type
unknown experiment type 
Contacts
Citation
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-3681.idf.txt
Sample and data relationshipE-GEOD-3681.sdrf.txt
Processed data (1)E-GEOD-3681.processed.1.zip
Array designsA-GEOD-3177.adf.txt, A-GEOD-3178.adf.txt
Links