E-GEOD-3624 - Transcription profiling of human dendritic cells from PLOSL patients show abnormalities in pathways of actin bundling and immune response
Submitted on 17 November 2005, released on 6 November 2008, last updated on 27 March 2012
This study was aimed to identify pathways associated with loss-of-function of the DAP12/TREM2 receptor complex and thus gain insight into pathogenesis of PLOSL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy). Transcript profiles of PLOSL patients' DCs showed differential expression of genes involved in actin bundling and immune response, but also for the stability of myelin and bone remodeling. Experiment Overall Design: Transcript profiles of in vitro differentiated DCs of three controls and five PLOSL patients were analyzed.
transcription profiling by array, disease state, individual genetic characteristics
Transcript profiles of dendritic cells of Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (PLOSL) patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response. Anna Kiialainen, Ville Veckman, Juha Saharinen, Juha Paloneva, Massimiliano Gentile, Panu Hakola, Dimitri Hemelsoet, Basil Ridha, Outi Kopra, Ilkka Julkunen, Leena Peltonen.