E-GEOD-3494 - Transcription profiling of human breast cancer samples to generate an expression signature for p53 status
Released on 4 April 2008, last updated on 27 March 2012
The biological tumor samples (ie, breast tumor specimens) consisted of freshly frozen breast tumors from a population-based cohort of 315 women representing 65% of all breast cancers resected in Uppsala County, Sweden, from January 1, 1987 to December 31, 1989. Estrogen receptor status was determined by biochemical assay as part of the routine clinical procedure. An experienced pathologist determined the Elston-Ellis grades of the tumors, classifying the tumors into low, medium and high-grade tumors. The clinico-pathological characteristics accompanying each tumor include p53 status, ER status, tumor grade, lymph node status and patient age. Experiment Overall Design: All tumor specimens were assessed on U133 A and B arrays.
transcription profiling by array, clinical history, co-expression, disease state
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Lance D Miller, Johanna Smeds, Joshy George, Vinsensius B Vega, Liza Vergara, Alexander Ploner, Yudi Pawitan, Per Hall, Sigrid Klaar, Edison T Liu, Jonas Bergh.