E-GEOD-32271 - Pax6 mutant neocortex vs. wild type
Released on 31 October 2011, last updated on 5 December 2011
Pax6 is a transcription factor with key functional roles in embryonic development. In order to identify downstream effectors of Pax6 in the developing cerebral cortex we performed microarray analysis. We compared gene expression profiles of cortical tissues isolated from wild type and Pax6-/- mouse embryos. In order to identify Pax6 downstream targets we carried out microarray analysis of Pax6-/- mutant mice. Pax6 is highly expressed in the mouse cerebral cortex at embryonic day E14.5, therefore we selected this tissue in order to compare gene expression profiles between wild type and Pax6-/- homozygous cortici. RNA samples were isolated from three mutant and three wild type embryos.
transcription profiling by array
Robert Geffers <email@example.com>, R Geffers, S Boppana, V Tarabykin
Cellular retinaldehyde-binding protein (CRALBP) is a direct downstream target of transcription factor Pax6. Boppana S, Scheglov A, Geffers R, Tarabykin V. , Europe PMC 21996446