E-GEOD-31457 - Gene expression in the adrenal glands of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
Released on 16 April 2013, last updated on 2 June 2014
We examined gene expression profiles in the rat adrenal glands using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis of hypertension in the SHR strains, we compared the gene expression levels at 3 and 6 weeks of age, isolated 407 genes showing a more than 4-fold increase or a less than 1/4-fold decrease. The rat adrenal glands derived from normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP) were examined. Each strain was run in triplicate.
transcription profiling by array
Daisuke Okuzaki, Hiromichi Yamanishi, Hiroshi Nojima, Kazunori Shimada, Momoko Yoshida, Yuko Watanabe
Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats. Yamamoto H, Okuzaki D, Yamanishi K, Xu Y, Watanabe Y, Yoshida M, Yamashita A, Goto N, Nishiguchi S, Shimada K, Nojima H, Yasunaga T, Okamura H, Matsunaga H, Yamanishi H. , Europe PMC 23525202