E-GEOD-31453 - Genome-wide analysis of gene expression patterns in the liver tumors of mir-122 knockout mice
Released on 6 August 2012, last updated on 13 August 2012
To invesigate the physiological roles of mir-122 in hepatocarcinogenesis, we performed expression profiling of the liver tumors of mir-122 knockout mice and the liver tissues of the control B6/129 mice. Total RNA was extracted from three tumors of mir-122 knockout mice and liver tissues of two control mice of 11 months of age; five tumors of mir-122 knockout mice and the liver tissues of three control mice of 14 months of age. Gene expression was quantified by robust multi-array analysis (RMA) using the Genomic Suite software from Partek.
transcription profiling by array
Ann-Ping Tsou <email@example.com>, Chu-Sui Hsu, Hua-Chien Chen, Shu-Jen Chen, Wei-Chih Tsai, Yi Huang
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, Hsu MT, Wu JC, Huang HD, Shiao MS, Hsiao M, Tsou AP. , Europe PMC 22820290