E-GEOD-2700 - Transcription profiling of human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X to identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma

Status
Submitted on 24 May 2005, released on 30 October 2007, last updated on 2 May 2014
Organism
Homo sapiens
Samples (7)
Array (1)
Protocols (5)
Description
Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1sg/ml tetracycline treatment to induce the expression of the genes. Results identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma.

Note that files GSM52180.txt and GSM52184.txt as downloaded from GEO are identical.
Experiment types
transcription profiling by array, cell type comparison, co-expression
Contact
Citation
HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. Belén Lucas, Karen Grigo, Silke Erdmann, Jörn Lausen, Ludger Klein-Hitpass, Gerhart U Ryffel. Oncogene 24(42):6418-31 (2005)
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-2700.idf.txt
Sample and data relationshipE-GEOD-2700.sdrf.txt
Processed data (1)E-GEOD-2700.processed.1.zip
Array designA-AFFY-33.adf.txt
Links