E-GEOD-19913 - Syndecan-2 and apoptosis in osteosarcoma

Status
Released on 23 September 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (6)
Description
Syndecan-2 was found to act as a tumor suppressor in osteosarcoma and to mediate the apoptotic response to cytotoxic agents. To determine new mechanisms that control cell survival and apoptosis in osteosarcoma cells, we aim to show target genes that are involved downstream of this proteoglycan during apoptosis induction. We aim to compare the modifications induced by syndecan-2 overexpression in two different human osteosarcoma cell lines using a lentiviral vector coding the human syndecan-2. Syndecan-2 lentiviral vector (SY) and control empty lentiviral vector (VV) were transducted in two different human osteosarcoma cell lines in a dye-swap experiment.
Experiment type
transcription profiling by array 
Contacts
Bernard Mari, Dominique Modrowski, Kevin Lebrigand, Oivia Fromigue, Pascal Barbry
Citation
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. Marion A, Dieudonn� FX, Pati�o-Garcia A, Lecanda F, Marie PJ, Modrowski D. , Europe PMC 21681744
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-19913.idf.txt
Sample and data relationshipE-GEOD-19913.sdrf.txt
Raw data (1)E-GEOD-19913.raw.1.zip
Processed data (1)E-GEOD-19913.processed.1.zip
Array designA-GEOD-1456.adf.txt
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