E-GEOD-19913 - Syndecan-2 and apoptosis in osteosarcoma
Released on 23 September 2013, last updated on 2 June 2014
Syndecan-2 was found to act as a tumor suppressor in osteosarcoma and to mediate the apoptotic response to cytotoxic agents. To determine new mechanisms that control cell survival and apoptosis in osteosarcoma cells, we aim to show target genes that are involved downstream of this proteoglycan during apoptosis induction. We aim to compare the modifications induced by syndecan-2 overexpression in two different human osteosarcoma cell lines using a lentiviral vector coding the human syndecan-2. Syndecan-2 lentiviral vector (SY) and control empty lentiviral vector (VV) were transducted in two different human osteosarcoma cell lines in a dye-swap experiment.
transcription profiling by array
Bernard Mari, Dominique Modrowski, Kevin Lebrigand, Oivia Fromigue, Pascal Barbry
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. Marion A, Dieudonnï¿½ FX, Patiï¿½o-Garcia A, Lecanda F, Marie PJ, Modrowski D. , Europe PMC 21681744