E-GEOD-17390 - A Dysregulated Proinflammatory Status in Preterm School-aged Children with PVL-induced Spastic Cerebral Palsy

Status
Submitted on 28 July 2009, released on 22 May 2010, last updated on 1 May 2014
Organism
Homo sapiens
Samples (10)
Array (1)
Protocols (8)
Description
Injury occurring during critical periods of development may have long-term effects on inflammatory responses. Periventricular leukomalacia (PVL) is the most common cause of cerebral palsy (CP) in preterm infant. Activated leukocytes are the main source of inflammatory cytokines that give rise to white matter damage and CP in preterm infant. Here, we tested the hypothesis that inflammation profiles as pathogenic mediators for the occurrence of PVL in the neonatal period may persist in preterm children with CP at school age. Five preterm children with PVL-induced CP and gestational age-matched five preterm children with normal neurodevelopment were recruited from follow up clinics. Proinflammatory gene expression in the PBMCs from preterm children were determined by Superarray PCR study.
Experiment type
transcription profiling by array 
Contacts
Chang-yi Lin <s5893153@mail.ncku.edu.tw>, Chang-Yi Lin, Chao-Ching Huang, Shan-Tair Wang, Ying-Chao Chang
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-17390.idf.txt
Sample and data relationshipE-GEOD-17390.sdrf.txt
Raw data (1)E-GEOD-17390.raw.1.zip
Processed data (1)E-GEOD-17390.processed.1.zip
Array designA-GEOD-8930.adf.txt
Links