E-GEOD-15372 - Expression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines.

Status
Released on 17 April 2009, last updated on 27 March 2012
Organism
Homo sapiens
Samples (10)
Array (1)
Protocols (16)
Description
Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis. To model the onset of drug resistance, we measured gene expression alterations associated with cisplatin resistance. We treated clonally derived, drug-sensitive A2780 epithelial ovarian cancer cells with increasing concentrations of cisplatin. After 5 cycles of drug selection, the isogenic drug-sensitive (parental A2780) and -resistant (Round5 A2780) cell lines were subjected to mRNA expression microarray analyses.
Experiment type
transcription profiling by array 
Contacts
Kenneth P Nephew, Meng Li
Citation
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-15372.idf.txt
Sample and data relationshipE-GEOD-15372.sdrf.txt
Raw data (1)E-GEOD-15372.raw.1.zip
Processed data (1)E-GEOD-15372.processed.1.zip
Array designA-AFFY-44.adf.txt
R ExpressionSetE-GEOD-15372.eSet.r
Links