E-GEOD-14518 - Endometrial profile of low-dose estradiol and tamoxifen combination therapy

Status
Submitted on 22 January 2009, released on 6 May 2010, last updated on 1 May 2014
Organism
Macaca fascicularis
Samples (16)
Array (1)
Protocols (6)
Description
Combination therapy with estrogen and a selective estrogen receptor modulator (SERM) is a promising approach to safely alleviate important side effects related to estrogen deficiency in women at high risk for breast cancer. Data related to endometrial safety of estrogen+SERM co-therapies are limited, however. The primary goal of this study was to evaluate the endometrial profile of low-dose E2 and Tam alone and in combination. In this study 16 postmenopausal female cynomolgus macaques were randomized to receive placebo, low-dose micronized estradiol (E2, 0.25 mg/1800 kcal), the SERM tamoxifen (Tam, 20 mg/1800 kcal), or E2+Tam in a parallel-arm design. Endometrial samples were collected after 4 months of treatment and used for microarray analysis.
Experiment type
transcription profiling by array 
Contacts
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-14518.idf.txt
Sample and data relationshipE-GEOD-14518.sdrf.txt
Raw data (1)E-GEOD-14518.raw.1.zip
Processed data (1)E-GEOD-14518.processed.1.zip
Array designA-AFFY-145.adf.txt
R ExpressionSetE-GEOD-14518.eSet.r
Links