E-GEOD-1432 - Transcription profiling time series of the response of human microglial cells to interferon gamma
Submitted on 25 May 2004, released on 3 August 2007, last updated on 27 March 2012
Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed a series of experiments to acertain the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. Primary human microglial cells were either untreated or treated with 200u/ml IFN-gamma. Affymetrix U133A chips were utilized. Four different tissue samples (B18, O, W, and Y20) were analyzed at the three time points.
transcription profiling by array, co-expression, compound treatment, individual comparison, time series
Transcriptional response of human microglial cells to interferon-gamma. R B Rock, S Hu, A Deshpande, S Munir, B J May, C A Baker, P K Peterson, V Kapur. Genes Immun 6(8):712-9 (2005)