E-GEOD-13637 - Transcription profiling by array of HUVEC cells after infection with H5N1 influenza virus
Released on 30 December 2009, last updated on 29 April 2015
To delineate specific patterns of signaling networks activated by H5N1 we used a comparative systems biology approach analyzing gene expression in endothelial cells infected with three different human and avian influenza strains of high and low pathogenicity. HUVECs were infected with either PR8, FPV or H5N1 virus. We used wildtype HUVEC or HUVEC transfected with a dominant negative mutant of IKK2 (block of the NF-kB signaling pathway).
transcription profiling by array
Dorothee Viemann <email@example.com>, Aloys Lueken, Helmut Wittkowski, Johannes Roth, Judith Friesenhagen, Mirco Schmolke, Stephan Ludwig, Yvonne Boergeling
Essential impact of NF-kappaB signaling on the H5N1 influenza A virus-induced transcriptome. Schmolke M, Viemann D, Roth J, Ludwig S.