E-GEOD-13017 - Early-induced genes of human regulatory CD4+CD25hi Treg and CD4+CD25- Th cells
Released on 20 April 2009, last updated on 27 January 2013
Goals and objectives of this study: to identify genes preferentially induced in human CD4+CD25hi Treg cells following T-cell activation with potential role for stabililization & maintenance of the regulatory program. Keywords: T-cell receptor stimulation, gene-regulation, comparative gene expression profiling Homo sapiens CD4+CD25- and CD4+CD25hi T cells were sorted from healthy individual donors and analyzed ex vivo (non-activated) or 1 day following T-cell receptor activation using anti-CD3/IL2 and anti-CD3/-CD28/IL2 (activated), respectively.
transcription profiling by array
Robert Geffers <firstname.lastname@example.org>, M Probst-Kepper, R Geffers
GARP: a key receptor controlling FOXP3 in human regulatory T cells. Probst-Kepper M, Geffers R, Krï¿½ger A, Viegas N, Erck C, Hecht HJ, Lï¿½nsdorf H, Roubin R, Moharregh-Khiabani D, Wagner K, Ocklenburg F, Jeron A, Garritsen H, Arstila TP, Kekï¿½lï¿½inen E, Balling R, Hauser H, Buer J, Weiss S. , Europe PMC 19453521