E-GEOD-12854 - Transcription profiling by array of human ovarian cancer cells over-expressing PKA regulatory subunits

Status
Released on 25 October 2008, last updated on 29 April 2015
Organism
Homo sapiens
Samples (9)
Array (1)
Protocols (6)
Description
The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of different experimental approaches has shown that the relative levels of type I and type II PKA in cells can play a major role in determining the balance between cell growth and differentiation. RI? transfected cells exhibit hyper-proliferative growth and RII? transfected cells revert to a relatively quiescent state. Profiling by microarray revealed equally profound changes in gene expression between RI?, RII?, and parental OVCAR cells.
Experiment types
transcription profiling by array, genetic modification design
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-12854.idf.txt
Sample and data relationshipE-GEOD-12854.sdrf.txt
Raw data (1)E-GEOD-12854.raw.1.zip
Processed data (1)E-GEOD-12854.processed.1.zip
Array designA-AFFY-44.adf.txt
Links