E-GEOD-12673 - Whole heart response to stable HIF-1alpha overexpression
Submitted on 3 September 2008, released on 15 May 2010, last updated on 1 May 2014
An oxygen stable form of HIF-1alpha was overexpressed in the hearts of mice, under tet-off control. Bi-allelic transgenic mice were created by crossing alpha-MHC promoter/tet transactivating protein expressing mice with tet responsive element promter/stable HIF-1alpha protein expressing mice. Mice were either, maintained on Doxycycline (inhibiting the expression of the HIF-1alpha transgene) or removed from doxycycline (inducing expression) for one or three days.
transcription profiling by array
Chad Brian Walton <firstname.lastname@example.org>, Chad B Walton, David Sutcliffe, Fred Kruse, Joel T Outten, Raffi Bekeredijan, Ralph V Shohet, Richard K Bruick, Robert D Gerard