E-GEOD-12654 - Transcription profiling of human prefrontal cortex (BA10)
Submitted on 3 September 2008, released on 25 October 2008, last updated on 27 March 2012
We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disorders, we explored the uniqueness of bipolar disorder and its similarity to other mental disorders at the molecular level. Notably, most of the altered gene expressions in each disease were not shared by one another, suggesting the molecular distinctiveness of these mental disorders. We found a tendency of downregulation of the genes encoding receptor, channels or transporters, and upregulation of the genes encoding stress response proteins or molecular chaperons in bipolar disorder. Altered expressions in bipolar disorder shared by other mental disorders mainly consisted of upregulation of the genes encoding proteins for transcription or translation. The genes identified in this study would be useful for the understanding of the pathophysiology of bipolar disorder, as well as the common pathophysiological background in major mental disorders at the molecular level. Experiment Overall Design: A total of 50 postmortem brains obtained from the Stanley Medical Research Institute were used for DNA microarray analysis. Fresh frozen samples were used for RNA extraction.
transcription profiling by array, unknown experiment type
Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. K Iwamoto, C Kakiuchi, M Bundo, K Ikeda, T Kato. Mol Psychiatry 9(4):406-16 (2004)