E-GEOD-11696 - Gene expression profile of M.tuberculosis espR (Rv3849) mutant
Submitted on 4 June 2008, released on 4 July 2008, last updated on 1 May 2014
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) is a key regulator of ESX-1. EspR activates transcription of an operon that includes three ESX-1 components, Rv3616c-Rv3614c, whose expression in turn promotes secretion of ESX-1 substrates. Keywords: Strain comparison Comparison of the global gene expression of three M.tb strains grown in log phase: Erdman strain of M.tb, espR transposon mutant, and the espR transposon mutant complemented with the espR gene
transcription profiling by array
Paolo Manzanillo <email@example.com>, Jeffery Cox, Sridharan Raghavan
Secreted transcription factor controls Mycobacterium tuberculosis virulence. Raghavan S, Manzanillo P, Chan K, Dovey C, Cox JS.