E-GEOD-11227 - Transcription profiling by array of human renal disease patients after nocturnal hemodialysis
Released on 13 January 2009, last updated on 27 August 2015
Nocturnal home hemodialysis (NHD) [5 – 6 times a week, 6-8 hours per session] augments uremia clearance and is associated with an increase in hemoglobin level. We have used microarray to have a global image of the changes at the gene expression. Experiment Overall Design: Sixteen stable end-stage renal disease patients (age: 47 ± 2 years; 9M) [mean ± SEM] were studied. Total RNA (TRNA) was isolated from whole blood before and after 3 months of established NHD. Gene expression before and after NHD was acquired through hybridizations on Human HG-U133_PLUS2 GeneChip and genes with differential gene expression were identified.
transcription profiling by array, unknown experiment type
Nocturnal hemodialysis improves erythropoietin responsiveness and growth of hematopoietic stem cells. Chan CT, Liu PP, Arab S, Jamal N, Messner HA.